The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism

Pharmacol Biochem Behav. 2001 Apr;68(4):677-83. doi: 10.1016/s0091-3057(01)00485-3.

Abstract

We have previously reported that MCI-225, a selective noradrenaline (NA) reuptake inhibitor with serotonin (5-HT)3 receptor antagonism, shows antidepressant-like properties in experiments using rodents. In this study, we investigated the effect of MCI-225 in anxiety models in comparison with diazepam, ondansetron, maprotiline, imipramine, and trazodone. In social interaction (SI) test in rats, MCI-225 (10 and 30 mg/kg, p.o.), diazepam (1-10 mg/kg, p.o.), and a selective 5-HT3 receptor antagonist ondansetron (1 mg/kg, p.o.) significantly increas

MeSH terms

  • Adrenergic Uptake Inhibitors / therapeutic use*
  • Animals
  • Anti-Anxiety Agents / therapeutic use*
  • Antidepressive Agents / therapeutic use
  • Anxiety / drug therapy*
  • Biguanides / therapeutic use
  • Male
  • Norepinephrine / antagonists & inhibitors
  • Ondansetron / therapeutic use
  • Piperazines / therapeutic use*
  • Psychotropic Drugs / therapeutic use*
  • Pyrimidines / therapeutic use*
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin* / physiology
  • Receptors, Serotonin, 5-HT3
  • Serotonin Antagonists / therapeutic use
  • Serotonin Receptor Agonists / therapeutic use

Substances

  • Adrenergic Uptake Inhibitors
  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Biguanides
  • Piperazines
  • Psychotropic Drugs
  • Pyrimidines
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT3
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • MCI 225
  • Ondansetron
  • 1-(3-chlorophenyl)biguanide
  • Norepinephrine