Abstract
We have previously reported that MCI-225, a selective noradrenaline (NA) reuptake inhibitor with serotonin (5-HT)3 receptor antagonism, shows antidepressant-like properties in experiments using rodents. In this study, we investigated the effect of MCI-225 in anxiety models in comparison with diazepam, ondansetron, maprotiline, imipramine, and trazodone. In social interaction (SI) test in rats, MCI-225 (10 and 30 mg/kg, p.o.), diazepam (1-10 mg/kg, p.o.), and a selective 5-HT3 receptor antagonist ondansetron (1 mg/kg, p.o.) significantly increas
MeSH terms
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Adrenergic Uptake Inhibitors / therapeutic use*
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Animals
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Anti-Anxiety Agents / therapeutic use*
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Antidepressive Agents / therapeutic use
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Anxiety / drug therapy*
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Biguanides / therapeutic use
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Male
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Norepinephrine / antagonists & inhibitors
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Ondansetron / therapeutic use
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Piperazines / therapeutic use*
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Psychotropic Drugs / therapeutic use*
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Pyrimidines / therapeutic use*
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Rats
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Rats, Wistar
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Receptors, Serotonin* / physiology
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Receptors, Serotonin, 5-HT3
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Serotonin Antagonists / therapeutic use
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Serotonin Receptor Agonists / therapeutic use
Substances
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Adrenergic Uptake Inhibitors
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Anti-Anxiety Agents
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Antidepressive Agents
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Biguanides
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Piperazines
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Psychotropic Drugs
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Pyrimidines
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT3
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Serotonin Antagonists
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Serotonin Receptor Agonists
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MCI 225
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Ondansetron
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1-(3-chlorophenyl)biguanide
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Norepinephrine