A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale

J R Lee; M S Yang; D S Jang; T J Ha; K M Park; C H Lee; Y H Kho; K H Park

doi:10.1055/s-2001-16477

A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale

Planta Med. 2001 Aug;67(6):585-7. doi: 10.1055/s-2001-16477.

Authors

J R Lee, M S Yang, D S Jang, T J Ha, K M Park, C H Lee, Y H Kho, K H Park

PMID: 11509991
DOI: 10.1055/s-2001-16477

Abstract

The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC(50) value of 6.2 microg/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crystallographic analysis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects*
Asteraceae / chemistry*
Crystallography, X-Ray
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Conformation
Plant Stems / chemistry
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
U937 Cells

Substances

Sesquiterpenes
borenolide