Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC)

Cytogenet Cell Genet. 2001;93(1-2):40-2. doi: 10.1159/000056945.

Abstract

The deoxynucleotide carrier (DNC) transports deoxynucleotides into mitochondria and is therefore essential for mtDNA synthesis. The human DNC gene (SLC25A19) spans about 16.5 kb and consists of nine exons with the translation start site in exon 4. It is located on chromosome 17q25.3. Three transcripts, which differ in their 5' ends and are generated by alternative splicing, have been identified.

MeSH terms

  • Alternative Splicing / genetics
  • Base Sequence
  • Carrier Proteins / genetics*
  • Chromosomes, Human, Pair 17 / genetics*
  • Cloning, Molecular
  • Exons / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns / genetics*
  • Mitochondria / metabolism*
  • Molecular Sequence Data
  • RNA Splice Sites / genetics
  • Sequence Analysis, DNA

Substances

  • Carrier Proteins
  • RNA Splice Sites

Associated data

  • GENBANK/AJ301616

Grants and funding