Abstract
Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC(50) values of 7 and 2 microg/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 microg/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 microg/mL).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Ascomycota / chemistry
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Candida albicans / drug effects
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Candida albicans / metabolism
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Cells, Cultured / drug effects
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Humans
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KB Cells / drug effects
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plasmodium falciparum / drug effects
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Plasmodium falciparum / metabolism
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Stereoisomerism
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Structure-Activity Relationship
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Thailand
Substances
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Antifungal Agents
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Lactones
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multiplolide A
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multiplolide B