Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex

J Nat Prod. 2001 Jul;64(7):965-7. doi: 10.1021/np000291p.

Abstract

Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC(50) values of 7 and 2 microg/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 microg/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 microg/mL).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Ascomycota / chemistry
  • Candida albicans / drug effects
  • Candida albicans / metabolism
  • Cells, Cultured / drug effects
  • Humans
  • KB Cells / drug effects
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plasmodium falciparum / drug effects
  • Plasmodium falciparum / metabolism
  • Stereoisomerism
  • Structure-Activity Relationship
  • Thailand

Substances

  • Antifungal Agents
  • Lactones
  • multiplolide A
  • multiplolide B