Endoscopic evaluation of the gastrotolerance of short-term antalgic treatment with low dose k-diclofenac: a comparison of ibuprofen and aspirin

I Mahé; S Mouly; E Mahé; M Diemer; A L Knellwolf; G Simoneau; C Caulin; J F Bergmann

doi:10.1046/j.1472-8206.2001.00004.x

Endoscopic evaluation of the gastrotolerance of short-term antalgic treatment with low dose k-diclofenac: a comparison of ibuprofen and aspirin

Fundam Clin Pharmacol. 2001 Feb;15(1):61-3. doi: 10.1046/j.1472-8206.2001.00004.x.

Authors

I Mahé¹, S Mouly, E Mahé, M Diemer, A L Knellwolf, G Simoneau, C Caulin, J F Bergmann

Affiliation

¹ Unité de Recherches Thérapeutiques, Hôpital Lariboisière, 2 rue Ambroise Paré, 75010 Paris, France.

PMID: 11468015
DOI: 10.1046/j.1472-8206.2001.00004.x

Abstract

In a short-term gastro-duodenal endoscopic study in 12 healthy volunteers, the gastrotoxicity was not different after intake of diclofenac-K 12.5 mg (0.33) or ibuprofen 200 mg (0.42, P=0.66) but significantly higher after aspirin 500 mg (2.67, P=0.002).

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Aspirin / administration & dosage*
Aspirin / adverse effects
Aspirin / therapeutic use
Diclofenac / administration & dosage*
Diclofenac / adverse effects
Diclofenac / therapeutic use
Duodenum / drug effects
Endoscopy, Gastrointestinal
Female
Humans
Ibuprofen / administration & dosage*
Ibuprofen / adverse effects
Ibuprofen / therapeutic use
Male
Pain / drug therapy
Single-Blind Method
Stomach / drug effects

Substances

Anti-Inflammatory Agents, Non-Steroidal
Diclofenac
Aspirin
Ibuprofen