Abstract
From a methanol extract of Artemisia caruifolia, which showed a moderate inhibitory activity on HIV-1 protease in a preliminary screening, N1,N5,N10-tri-p-coumaroylspermidine and three dicaffeoylquinic acids were isolated. The former compound was found to appreciably inhibit HIV-1 protease. Of related amides which were chemically synthesized, N1,N5,N10,N14-tetra-p-coumaroylspermine and N1,N4,N7,N10,N13-penta-p-coumaroylte-traethylenepentamine inhibited HIV-1 protease more potently than N1,N5,N10-tri-p-coumaroylspermidine.
MeSH terms
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Amides / isolation & purification
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Amides / pharmacology
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Artemisia / chemistry*
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Coumaric Acids / chemistry*
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Coumaric Acids / pharmacology*
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HIV Protease Inhibitors / isolation & purification*
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HIV Protease Inhibitors / pharmacology*
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Magnetic Resonance Spectroscopy
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Plant Extracts / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Spermidine / analogs & derivatives
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Spermidine / chemistry*
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Spermidine / pharmacology*
Substances
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Amides
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Coumaric Acids
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HIV Protease Inhibitors
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N1,N5,N10-tris(4-coumaroyl)spermidine
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Plant Extracts
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Spermidine