Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: a potential tumor photosensitizer

T Y Wang; H L Liu; J R Chen; F G Liu; Y Gu; J S Ma

doi:10.1016/s0960-894x(01)00363-8

Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: a potential tumor photosensitizer

Bioorg Med Chem Lett. 2001 Aug 6;11(15):2049-52. doi: 10.1016/s0960-894x(01)00363-8.

Authors

T Y Wang¹, H L Liu, J R Chen, F G Liu, Y Gu, J S Ma

Affiliation

¹ Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China.

PMID: 11454478
DOI: 10.1016/s0960-894x(01)00363-8

Abstract

The synthesis, photophysical properties of diphenyl-2,3-dihydroxychlorin (DPCOH) and its photocytotoxicity to tumor cells are described. DPCOH exhibits photodynamic activity in terms of type I and type II mechanisms under irradiation. The quantum yield of (1)O(2) in CHCl(3) is 0.7. For the photocytotoxicity to tumor cells, DPCOH proved to be 200 times more potent than HPD, and the dark toxicity is low (dark IC(90)>32 microg/mL).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biphenyl Compounds / chemical synthesis*
Biphenyl Compounds / pharmacology*
Electron Spin Resonance Spectroscopy
Humans
Lighting
Photochemotherapy
Photosensitizing Agents / chemical synthesis*
Photosensitizing Agents / pharmacology*
Porphyrins / chemical synthesis
Porphyrins / chemistry*
Porphyrins / pharmacology
Tumor Cells, Cultured / drug effects

Substances

Biphenyl Compounds
Photosensitizing Agents
Porphyrins
diphenyl-2,3-dihydroxychlorin
chlorin