Abstract
Preparative RP-HPLC analysis of a methanol extract of the seeds of Centaurea cyanus afforded four indole alkaloids: moschamine, cis-moschamine, centcyamine and cis-centcyamine, the latter two being new natural products. Structures of these compounds were elucidated by comprehensive spectroscopic analyses. General toxicity of the isolates was determined by Brine Shrimp Lethality bioassay.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / toxicity
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Animals
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Artemia / drug effects
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Asteraceae / chemistry*
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Chromatography, High Pressure Liquid
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Indoles / chemistry
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Indoles / isolation & purification*
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Indoles / toxicity
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Plants, Medicinal / chemistry*
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Seeds / chemistry
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Spectrophotometry, Ultraviolet