Abstract
The aqueous extract of Desmodium gangeticum DC. (Leguminosae) showed no analgesic activity in the hot plate method, but it showed severe anti-writhing activity in the acetic acid-induced abdominal writhing assay. It exhibited moderate central nervous system depressant activity in the spontaneous motor activity, hole cross, and open field tests and hole board tests. The effects of this extract on locomotion were compared with some standard CNS drugs.
MeSH terms
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Analgesics, Opioid / pharmacology
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Animals
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Behavior, Animal / drug effects
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Central Nervous System / drug effects*
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Central Nervous System Agents / pharmacology*
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Dose-Response Relationship, Drug
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Fabaceae / chemistry*
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Female
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India
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Male
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Medicine, Ayurvedic
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Mice
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Morphine / pharmacology
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Motor Activity / drug effects
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Pain Measurement / drug effects
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Phytotherapy
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Plant Extracts / pharmacology*
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Plants, Medicinal / chemistry*
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Reaction Time / drug effects
Substances
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Analgesics, Opioid
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Central Nervous System Agents
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Plant Extracts
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Morphine