Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate

J A Castro Hermida; M E Ares-Mazás; L Nieto Reyes; F Otero Espinar; J Blanco Méndez

doi:10.1007/s004360000359

Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate

Parasitol Res. 2001 Jun;87(6):449-52. doi: 10.1007/s004360000359.

Authors

J A Castro Hermida¹, M E Ares-Mazás, L Nieto Reyes, F Otero Espinar, J Blanco Méndez

Affiliation

¹ Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, La Coruña, Spain.

PMID: 11411943
DOI: 10.1007/s004360000359

Abstract

The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amebicides / therapeutic use*
Animals
Cattle
Cryptosporidiosis / drug therapy*
Cryptosporidiosis / parasitology
Cryptosporidium parvum / isolation & purification*
Cryptosporidium parvum / physiology
Cyclodextrins / therapeutic use*
Disease Models, Animal
Drug Carriers
Drug Therapy, Combination
Excipients
Furans / therapeutic use*
Mice
Parasite Egg Count
beta-Cyclodextrins*

Substances

Amebicides
Cyclodextrins
Drug Carriers
Excipients
Furans
beta-Cyclodextrins
betadex
diloxanide furoate