Frequency of celiac disease in individuals with Down syndrome in the United States

Clin Pediatr (Phila). 2001 May;40(5):249-52. doi: 10.1177/000992280104000502.

Abstract

Ninety-three individuals with Down syndrome (DS) were screened to investigate the prevalence of celiac disease (CD) in the United States. Five of the 93 individuals were antiendomysial antibody (EMA) positive. Of the 5 who tested positive for EMA, 4 were biopsied, 1 refused biopsy. Three of the 4 individuals biopsied manifested changes of CD on small bowel biopsy. This gives a frequency of 3.2% of confirmed CD in our DS individuals and suggests the need for periodic screening for celiac disease in this population.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Algorithms*
  • Autoantibodies / blood
  • Biopsy
  • Celiac Disease / diagnosis
  • Celiac Disease / epidemiology*
  • Celiac Disease / etiology
  • Child
  • Child, Preschool
  • Down Syndrome / complications
  • Down Syndrome / immunology
  • Female
  • Gliadin / immunology
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Infant
  • Male
  • Mass Screening / methods*
  • Muscle Fibers, Skeletal / immunology
  • Prevalence
  • Prospective Studies
  • United States / epidemiology

Substances

  • Autoantibodies
  • Immunoglobulin A
  • Immunoglobulin G
  • Gliadin