[Liberation of active agents from coherent emulsions]

Acta Pharm Hung. 2000 Jul-Dec;70(3-6):97-102.
[Article in Hungarian]

Abstract

Drug release from coherent emulsions containing high water concentration (50-80 w/w%) was studied. Composition of coherent systems was as follows: self-emulsifying wax and preserved water. Griseofulvin was applied as active agent in suspended form. The liberation experiments were carried out with Hanson vertical diffusion cell, acceptor phase was distilled water, membrane was celophane one. It was established that the time course of liberation of griseofulvin from coherent emulsions can be characterized with a multiplicative function and the exponent of this function is about 0.5. The quantity of released drug increased linearly with the water content and it decreased exponentially with the viscosity of coherent emulsions.

Publication types

  • English Abstract

MeSH terms

  • Delayed-Action Preparations
  • Diffusion
  • Emulsions / chemistry*
  • Griseofulvin / chemistry*
  • Kinetics

Substances

  • Delayed-Action Preparations
  • Emulsions
  • Griseofulvin