Successful treatment of metronidazole- and albendazole-resistant giardiasis with nitazoxanide in a patient with acquired immunodeficiency syndrome

P Abboud; V Lemée; G Gargala; P Brasseur; J J Ballet; F Borsa-Lebas; F Caron; L Favennec

doi:10.1086/320751

Successful treatment of metronidazole- and albendazole-resistant giardiasis with nitazoxanide in a patient with acquired immunodeficiency syndrome

Clin Infect Dis. 2001 Jun 15;32(12):1792-4. doi: 10.1086/320751. Epub 2001 May 9.

Authors

P Abboud¹, V Lemée, G Gargala, P Brasseur, J J Ballet, F Borsa-Lebas, F Caron, L Favennec

Affiliation

¹ Service de Maladies Infectieuses, Centre Hospitalier Universitaire Ch. Nicolle, Rouen, France.

PMID: 11360222
DOI: 10.1086/320751

Abstract

A case of metronidazole- and albendazole-resistant giardiasis in a patient with the acquired immunodeficiency syndrome was successfully treated with nitazoxanide (1.5 g twice a day for 30 days). Animal studies and in vitro assays showed that the isolate was resistant to both metronidazole and albendazole and susceptible to nitazoxanide.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

AIDS-Related Opportunistic Infections / drug therapy*
AIDS-Related Opportunistic Infections / immunology
AIDS-Related Opportunistic Infections / parasitology
Adult
Albendazole / pharmacology*
Animals
Antiprotozoal Agents / administration & dosage
Antiprotozoal Agents / pharmacology
Antiprotozoal Agents / therapeutic use*
Drug Resistance, Microbial
Giardia lamblia / drug effects
Giardia lamblia / isolation & purification
Giardiasis / drug therapy*
Giardiasis / immunology
Giardiasis / parasitology
Humans
Male
Metronidazole / pharmacology*
Nitro Compounds
Thiazoles / administration & dosage
Thiazoles / therapeutic use*
Treatment Outcome

Substances

Antiprotozoal Agents
Nitro Compounds
Thiazoles
Metronidazole
Albendazole
nitazoxanide