Evidence of grave vitamin A deficiency among lactating women in the semi-arid rural area of Makhaza in Zimbabwe. A population-based study

Eur J Clin Nutr. 2001 Apr;55(4):229-34. doi: 10.1038/sj.ejcn.1601138.

Abstract

Objective: To assess the vitamin A and iron status of lactating women.

Design: A population-based cross-sectional descriptive study.

Setting: A semi-arid rural area of Makhaza in Zimbabwe.

Subjects: Two hundred and seven lactating women with babies aged 2-12 months.

Methods: Serum retinol (SR) was measured by HPLC, serum ferritin (SF) by ELIZA, haemoglobin (Hb) by HemoCue and C-reactive protein (CRP) by a turbo metric method. A seven-day recall of consumption of vitamin A containing foods was recorded.

Main outcome measures: Relative dose response (RDR), SR, SF, Hb and CRP.

Results: Dark green leafy vegetables were the main sources of vitamin A; retinol-containing foods and yellow to red fruits and vegetables were rarely consumed. Five women had elevated CRP and these women had lower SR (P < 0.001) than the rest. Forty percent of the women had vitamin A deficiency (SR < 20 microg/dl), 76% had low liver stores of vitamin A (RDR > 20%) while 15 women had both abnormal SR and abnormal RDR. Forty percent had anaemia (Hb < 12 g/l) while 12% had iron deficiency (SF < 12 microg/dl) and 4% (n = 7) had iron deficiency anaemia.

Conclusion: Vitamin A and iron deficiencies are problems of public health significance among the lactating women in the Makhaza area.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anemia / blood
  • Anemia / epidemiology*
  • Anemia, Iron-Deficiency / epidemiology
  • C-Reactive Protein / analysis
  • Cross-Sectional Studies
  • Female
  • Ferritins / blood
  • Hemoglobins / metabolism
  • Humans
  • Iron / blood*
  • Lactation*
  • Middle Aged
  • Nutritional Status*
  • Rural Health
  • Vegetables
  • Vitamin A / administration & dosage
  • Vitamin A / blood*
  • Vitamin A Deficiency / blood
  • Vitamin A Deficiency / epidemiology*
  • Women's Health
  • Zimbabwe / epidemiology

Substances

  • Hemoglobins
  • Vitamin A
  • C-Reactive Protein
  • Ferritins
  • Iron