Synthesis of a sulfahydantoin library

J Comb Chem. 2001 May-Jun;3(3):290-300. doi: 10.1021/cc000111u.

Abstract

A five-step solid-phase synthesis of sulfahydantoins from alpha-amino acids and aldehydes was developed. The synthetic method allows the use of hindered amino acids, including Val, Phg, and Aib, and use of aromatic aldehydes substituted with electron-withdrawing and -donating groups. Some limitations were encountered with amino acids with reactive side chains. A small but diverse library of compounds was produced for biological testing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Amino Acids / chemistry*
  • Combinatorial Chemistry Techniques
  • Hydantoins / chemical synthesis*
  • Molecular Structure
  • Spectrophotometry, Ultraviolet
  • Sulfur Compounds / chemical synthesis*
  • Thiazoles / chemistry*

Substances

  • Aldehydes
  • Amino Acids
  • Hydantoins
  • Sulfur Compounds
  • Thiazoles