Abstract
Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria. Specific examples were effective permeabilizers of the outer membranes of many strains of multidrug-resistant Gram-negative bacteria and sensitized these to hydrophobic antibiotics. We also prepared a new cholic acid derivative with improved apparent selectivity for prokaryote membranes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Cholic Acid / chemical synthesis
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Cholic Acid / chemistry
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Cholic Acid / pharmacology*
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Drug Resistance, Multiple
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Escherichia coli / drug effects
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Humans
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Microbial Sensitivity Tests
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Salmonella typhimurium / drug effects
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Staphylococcus aureus / drug effects
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Streptococcus pneumoniae / drug effects
Substances
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Anti-Bacterial Agents
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Cholic Acid