Real-time spatial compound imaging (SonoCT) is an ultrasound technique that uses electronic beam steering of a transducer array to rapidly acquire several (three to nine) overlapping scans of an object from different view angles. These single-angle scans are averaged to form a multiangle compound image that is updated in real time with each subsequent scan. Compound imaging shows improved image quality compared with conventional ultrasound, primarily because of reduction of speckle, clutter, and other acoustic artifacts. Early clinical experience suggests that real-time spatial compound imaging can provide improved contrast resolution and tissue differentiation that is beneficial for imaging the breast, peripheral blood vessels, and musculoskeletal injuries. Future development of real-time spatial compound imaging will help address the bulk of general imaging applications by extending this technology to curved array transducers, tissue harmonics, panoramic imaging, and three-dimensional sonography.