Abstract
Unusual chemicals produced by the-'blue oyster' diatom, Haslea ostrearia, include the water-soluble blue pigment marennine and numerous polyunsaturated sesterterpene oils or haslenes. Aqueous extracts of the alga exhibit in vitro and in vivo activities against human lung cancer cells and anti-HIV effects. Here we report that three haslenes also demonstrate in vitro cytostatic action against a human lung cancer cell line. The most active haslene is the most unsaturated and unsaturation in the haslenes increases with increasing algal growth temperature.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry*
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Alkenes / pharmacology
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Animals
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Carcinoma, Squamous Cell
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Cell Survival / drug effects
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Diatoms / chemistry*
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HIV / drug effects
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Humans
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Lung Neoplasms
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Mice
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / toxicity
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Plant Oils / chemistry*
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Plant Oils / pharmacology
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Plant Oils / toxicity
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Terpenes / chemistry*
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Terpenes / pharmacology
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Thermodynamics
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Tumor Cells, Cultured
Substances
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Alkenes
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Anti-HIV Agents
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Plant Oils
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Terpenes