Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids

Bioorg Med Chem Lett. 2001 Mar 26;11(6):811-4. doi: 10.1016/s0960-894x(01)00067-1.

Abstract

The syntheses and antitumor activity of three paclitaxel-chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Agents, Alkylating / chemistry
  • Antineoplastic Agents, Alkylating / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Chlorambucil / chemistry
  • Chlorambucil / pharmacology
  • Disease Models, Animal
  • Female
  • Humans
  • Inhibitory Concentration 50
  • Mice
  • Neoplasm Transplantation
  • Ovarian Neoplasms / drug therapy
  • Paclitaxel / chemistry
  • Paclitaxel / pharmacology
  • Sarcoma / drug therapy
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Antineoplastic Agents, Phytogenic
  • Chlorambucil
  • Paclitaxel