Cigarette smoking during pregnancy increases the risk of oxidative damage and induces not only intrauterine foetal growth retardation, but also causes disturbances in postnatal growth and development. In the presented studies oxidative damage was estimated through the measurement of lipid peroxides concentration and the level of some antioxidants in placenta and in cord blood of newborns whose mothers smoked during pregnancy. We observed that the concentration of lipid peroxides was higher in cord blood and in placenta tissue (8%) than in the newborns of non-smoking mothers, but the activity of superoxide dismutase and glutathione peroxidase were lower by 20% and 16% respectively. Plasma level of vitamin A (p<0.005), vitamin E (p<0.05), fS-carotene (p< 0.0001) and total plasma antioxidant capacity (p<0.05) were significantly lower in the newborn of smoking than the non-smoking mother group. It is suggested that placental tissue protected the foetus against oxidative stress, but not sufficiently. Antioxidant activities of cord blood may also be insufficient in dismutation of free radicals and their detoxication in order to protect newborns against smoking dependent metabolic disturbances.