Linear IgA bullous dermatosis induced by atorvastatin

J Am Acad Dermatol. 2001 Apr;44(4):689-92. doi: 10.1067/mjd.2001.113462.

Abstract

Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disease characterized by circulating IgA antibodies binding the basement membrane zone. In most cases the origin is not clear, but in a minority of cases LABD is drug induced. We describe a patient in whom linear IgA disease developed shortly after beginning therapy with atorvastatin. In Western blotting analysis we detected IgA and IgG class antibodies targeting a 97-kd protein. To our knowledge this is the first reported case of atorvastatin-induced LABD.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticholesteremic Agents / adverse effects*
  • Atorvastatin
  • Drug Eruptions / etiology*
  • Drug Eruptions / immunology
  • Heptanoic Acids / adverse effects*
  • Humans
  • Immunoglobulin A*
  • Male
  • Middle Aged
  • Pyrroles / adverse effects*
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Skin Diseases, Vesiculobullous / immunology

Substances

  • Anticholesteremic Agents
  • Heptanoic Acids
  • Immunoglobulin A
  • Pyrroles
  • Atorvastatin