Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration

Eur J Med Chem. 2000 Dec;35(12):1109-13. doi: 10.1016/s0223-5234(00)01193-4.

Abstract

The in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha-D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta-anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta-anomers, even at 1x10 mol ratio without any cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticarcinogenic Agents / chemistry
  • Anticarcinogenic Agents / pharmacology*
  • Cell Line
  • Glycolipids / chemistry
  • Glycolipids / pharmacology*
  • Herpesvirus 4, Human / physiology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Tetradecanoylphorbol Acetate / pharmacology
  • Virus Activation / drug effects

Substances

  • Anticarcinogenic Agents
  • Glycolipids
  • Tetradecanoylphorbol Acetate