[Preparation and anti-HIV activity study of baicalien and its benzylated derivatives]

J Zhao; Z P Zhang; H S Chen; X H Chen; X Q Zhang

[Preparation and anti-HIV activity study of baicalien and its benzylated derivatives]

Yao Xue Xue Bao. 1997;32(2):140-3.

[Article in Chinese]

Authors

J Zhao¹, Z P Zhang, H S Chen, X H Chen, X Q Zhang

Affiliation

¹ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and the Peking Union Medical College, Beijing 100050.

PMID: 11243200

Abstract

Baicalein (1) was prepared from baicalin by acid hydrolysis with yield of 24%. 5, 6-Dibenzyl-7-hydroxyl-flanone (4) and 6-benzyl-5, 7-dihydroxyl-flanone (5) were obtained by using different benzylating agents, and then hydrolyzing those benzylated compounds. The total yield of (4) and (5) were 5.9% and 5%, respectively. Both 4 and 5 were less effective than baicalien on inhibition of HIV-1 RT in vitro.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemical synthesis*
Anti-HIV Agents / pharmacology
Flavanones*
Flavonoids / chemical synthesis*
Flavonoids / chemistry
Flavonoids / pharmacology
HIV Reverse Transcriptase / drug effects
Hydrolysis
Reverse Transcriptase Inhibitors / chemical synthesis
Reverse Transcriptase Inhibitors / pharmacology

Substances

Anti-HIV Agents
Flavanones
Flavonoids
Reverse Transcriptase Inhibitors
baicalin
baicalein
HIV Reverse Transcriptase