Abstract
The synthesis of new [1]benzopyrano[3',4':5,6]pyrano[2,3-d]pyrimidines and related heterocycles has been reported. The key intermediate 2-amino-3-cyano-4-methyl-4H,5H-pyrano[3,2-c][1]benzopyran-5-one (3) was obtained in one pot synthesis from the reaction of 4-hydroxycoumarin and acetaldehyde-malononitrile (2). The antimicrobial screening was performed for some of the synthesized compounds.
MeSH terms
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4-Hydroxycoumarins / chemical synthesis*
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4-Hydroxycoumarins / pharmacology
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Bacteria / drug effects
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Coumarins / chemistry*
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Coumarins / pharmacology
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Cyclization
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Fungi / drug effects
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Microbial Sensitivity Tests
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Pyrimidines / chemistry*
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Pyrimidines / pharmacology
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Spectroscopy, Fourier Transform Infrared
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Triazines / chemistry*
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Triazines / pharmacology
Substances
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4-Hydroxycoumarins
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Coumarins
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Pyrimidines
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Triazines