Antimycobacterial and antiplasmodial cyclodepsipeptides from the insect pathogenic fungus Paecilomyces tenuipes BCC 1614

Planta Med. 2000 Dec;66(8):756-8. doi: 10.1055/s-2000-9776.

Abstract

Bioassay-guided fractionation of the crude extract from the insect pathogenic fungus Paecilomyces tenuipes BCC 1614 led to the isolation and identification of two antimycobacterial and antiplasmodial cyclodepsipeptides, beauvericin and beauvericin A.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / isolation & purification*
  • Antitubercular Agents / pharmacology
  • Ascomycota / chemistry*
  • Drug Screening Assays, Antitumor
  • Humans
  • Insecta / microbiology*
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology

Substances

  • Antimalarials
  • Antitubercular Agents
  • Peptides, Cyclic