Vitiligo is an acute disease of skin with inflammation which means damage of melanocites, their defined partial paint lack. It is a frequent sickness which is very conspicuous and disturbing illness. For its treatment, systematically and topically psoralen-derivatives, UV-A radiation and other possibilities are used. Metoxsalen is one of them which is practically insoluble in water. Authors planned to increase the solubility of the pharmacon, and they studied with in vitro diffusion method, how the type of the emulsions influence the liberation and diffusion of metoxsalen.