Cell cycle. License withheld--geminin blocks DNA replication

Science. 2000 Dec 22;290(5500):2271-3. doi: 10.1126/science.290.5500.2271.

Abstract

A cell ensures that its genome is replicated only once during its division cycle through a process called licensing. In an enlightening Perspective, Lygerou and Nurse explain how binding of the Geminin protein to Cdt1 blocks the binding of licensing factors to chromatin, inhibiting the onset of S phase (Wohlschlegel et al.).

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / metabolism*
  • Cell Cycle Proteins / pharmacology
  • Cell Cycle*
  • Cell Nucleus / metabolism
  • Chromatin / metabolism*
  • DNA Damage
  • DNA Helicases / metabolism
  • DNA Replication* / drug effects
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • Evolution, Molecular
  • Geminin
  • Humans
  • Interphase
  • Metaphase
  • Mitosis
  • Models, Biological
  • Origin Recognition Complex
  • S Phase
  • Xenopus
  • Xenopus Proteins

Substances

  • CDT1 protein, human
  • Cell Cycle Proteins
  • Chromatin
  • DNA-Binding Proteins
  • GMNN protein, Xenopus
  • GMNN protein, human
  • Geminin
  • Origin Recognition Complex
  • Xenopus Proteins
  • DNA Helicases