[Analysis of regions determining resistence to fluoroquinolones in genes gyrA and parC in clinical isolates of Mycoplasma hominis]

A E Gushchin; V G Ladygina; V M Govorun; A M Taraskina; A M Savicheva

[Analysis of regions determining resistence to fluoroquinolones in genes gyrA and parC in clinical isolates of Mycoplasma hominis]

Mol Gen Mikrobiol Virusol. 2000:(4):33-5.

[Article in Russian]

Authors

A E Gushchin¹, V G Ladygina, V M Govorun, A M Taraskina, A M Savicheva

Affiliation

¹ Laboratory of Gene Engineering and Immunogenetics, Institute of Physico-Chemical Medicine, Ministry of Health of Russian Federation, Moscow, St. Petersburg.

PMID: 11186458

Abstract

Fifteen strains of M. hominis isolated from patients with urogenital inflammations were analyzed. Variations in the quinolone resistance-determining regions (QRDR) have been found in fluoroquinolone-resistant M. hominis clinical isolates in comparison with the reference PG21 strain. In one isolate, parC had Asn substitute at position 91.

Publication types

English Abstract

MeSH terms

Anti-Infective Agents / pharmacology*
Base Sequence
DNA Gyrase
DNA Primers
DNA Topoisomerase IV
DNA Topoisomerases, Type II / genetics*
Drug Resistance, Microbial / genetics*
Fluoroquinolones
Mycoplasma hominis / drug effects*
Mycoplasma hominis / genetics

Substances

Anti-Infective Agents
DNA Primers
Fluoroquinolones
DNA Topoisomerase IV
DNA Gyrase
DNA Topoisomerases, Type II