Cerebroprotective effects of diquertin and ascorbic acid

Bull Exp Biol Med. 2000 Nov;130(11):1080-3.

Abstract

Electron microscopy and electrophysiological studies revealed pronounced structural and functional changes in the brain cortex in rats with experimental cerebral ischemia. Repeated administration of diquertin and ascorbic acid significantly attenuates ischemic damage induced by circulatory disturbances.

MeSH terms

  • Alpha Rhythm / drug effects
  • Animals
  • Antioxidants / therapeutic use*
  • Ascorbic Acid / therapeutic use*
  • Beta Rhythm / drug effects
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / pathology
  • Brain Ischemia / physiopathology
  • Cerebral Cortex / injuries
  • Cerebral Cortex / pathology*
  • Parietal Lobe / pathology
  • Protective Agents / pharmacology
  • Quercetin / analogs & derivatives*
  • Quercetin / therapeutic use*
  • Rats
  • Rats, Wistar
  • Theta Rhythm / drug effects

Substances

  • Antioxidants
  • Protective Agents
  • Quercetin
  • Ascorbic Acid