Additional cytotoxic polyacetylenes from the marine sponge Petrosia species

Y J Lim; H S Park; K S Im; C Lee; J Hong; M Lee; D Kim Dk; J H Jung

doi:10.1021/np000252d

Additional cytotoxic polyacetylenes from the marine sponge Petrosia species

J Nat Prod. 2001 Jan;64(1):46-53. doi: 10.1021/np000252d.

Authors

Y J Lim¹, H S Park, K S Im, C Lee, J Hong, M Lee, D Kim Dk, J H Jung

Affiliation

¹ College of Pharmacy, Pusan National University, Pusan 609-735, Korea, Korea Research Institute of Chemical Technology, Taejon, Korea.

PMID: 11170665
DOI: 10.1021/np000252d

Abstract

Ten new polyacetylenic alcohols (1-6, 8-11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1-11 were further evaluated for in vitro inhibitory activity on DNA replication.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Chromatography, High Pressure Liquid
DNA Replication / drug effects
DNA, Viral / chemistry
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Porifera / chemistry*
Simian virus 40 / chemistry
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured

Substances

Antineoplastic Agents
DNA, Viral