N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus fusarium

Phytochemistry. 2000 Oct;55(3):223-6. doi: 10.1016/s0031-9422(00)00280-6.

Abstract

N-Methylsansalvamide (1), a new cyclic depsipeptide, was isolated from extracts of a cultured marine fungus, strain CNL-619, identified as a member of the genus Fusarium. N-Methylsansalvamide exhibits weak in vitro cytotoxicity in the NCI human tumor cell line screen (GI50 8.3 microM). The structure of 1 was determined by combined spectral and chemical methods.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Fusarium / chemistry*
  • Humans
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Tumor Cells, Cultured
  • Water Microbiology

Substances

  • Antineoplastic Agents
  • N-Methylsansalvamide
  • Peptides, Cyclic