A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin)

Bioorg Med Chem Lett. 2001 Jan 8;11(1):67-9. doi: 10.1016/s0960-894x(00)00594-1.

Abstract

2-Beta-D-ribofuranosylimidazole-4-carboxamide, an imidazole analogue of the antitumor agent tiazofurin, was synthesized and evaluated for the growth inhibitory activity of human myelogenous leukemia K562 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Division / drug effects
  • Humans
  • IMP Dehydrogenase / antagonists & inhibitors
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Imidazoles / pharmacology*
  • K562 Cells
  • Monosaccharides / chemical synthesis*
  • Monosaccharides / pharmacology*
  • Ribavirin / analogs & derivatives*
  • Ribavirin / chemical synthesis*
  • Ribavirin / chemistry
  • Ribavirin / pharmacology*

Substances

  • 2-ribofuranosylimidazole-4-carboxamide
  • Antineoplastic Agents
  • Imidazoles
  • Monosaccharides
  • Ribavirin
  • IMP Dehydrogenase
  • tiazofurin