Abstract
2-Beta-D-ribofuranosylimidazole-4-carboxamide, an imidazole analogue of the antitumor agent tiazofurin, was synthesized and evaluated for the growth inhibitory activity of human myelogenous leukemia K562 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Division / drug effects
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Humans
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IMP Dehydrogenase / antagonists & inhibitors
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Imidazoles / pharmacology*
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K562 Cells
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Monosaccharides / chemical synthesis*
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Monosaccharides / pharmacology*
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Ribavirin / analogs & derivatives*
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Ribavirin / chemical synthesis*
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Ribavirin / chemistry
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Ribavirin / pharmacology*
Substances
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2-ribofuranosylimidazole-4-carboxamide
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Antineoplastic Agents
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Imidazoles
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Monosaccharides
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Ribavirin
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IMP Dehydrogenase
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tiazofurin