Abstract
Our report concerns a patient with a climacterium praecox and an X-chromosomal anomaly (86% 46, XX; 7% 47, XXX; 7% 45, X0) desiring to give birth. She conceived once after down-regulation of the gonadotrophins by means of a cyclical hormone replacement therapy followed by gonadotrophin stimulation, as well as a second time under down-regulation with a GnRH-analogue and gonadotrophin stimulation. On the basis of the case report and of the literature, a possible interval therapy in such a patient, especially one even with increasing ovarian insufficiency, will be portrayed and discussed.
MeSH terms
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Adult
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Down-Regulation
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Estradiol / analogs & derivatives*
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Estradiol / therapeutic use*
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Female
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Fertility Agents, Female / therapeutic use*
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Gonadotropin-Releasing Hormone / analogs & derivatives
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Gonadotropin-Releasing Hormone / physiology
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Humans
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Infertility, Female / drug therapy*
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Infertility, Female / etiology
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Infertility, Female / genetics
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Menotropins / therapeutic use*
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Pregnancy
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Primary Ovarian Insufficiency / complications
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Primary Ovarian Insufficiency / genetics*
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Sex Chromosome Aberrations*
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X Chromosome*
Substances
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Fertility Agents, Female
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Gonadotropin-Releasing Hormone
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Estradiol
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Menotropins