Abstract
In a retrospective 10-year analysis of 3,536 patient-unique isolates, Acinetobacter baumannii imipenem susceptibility declined from 98.1 (1990) to 64.1% (2000), and ciprofloxacin susceptibility decreased from 50.5 to 13.1%. Imipenem median zone diameters decreased from 27. 7 (1997) to 18.8 mm (2000). No outbreaks were detected. Two clusters were identified for 41 strains genotyped by pulsed-field gel electrophoresis, but imipenem resistance was not clonal.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter / drug effects*
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Acinetobacter / genetics
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Acinetobacter Infections / epidemiology
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Acinetobacter Infections / microbiology*
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Anti-Bacterial Agents / pharmacology*
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Anti-Infective Agents / pharmacology
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Ciprofloxacin / pharmacology
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Drug Resistance, Microbial / genetics
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Electrophoresis, Gel, Pulsed-Field
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Hospitals, Teaching
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Humans
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Imipenem / pharmacology*
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Israel / epidemiology
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Microbial Sensitivity Tests
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Retrospective Studies
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Thienamycins / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Thienamycins
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Ciprofloxacin
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Imipenem