Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain

S Begon; G Pickering; A Eschalier; C Dubray

doi:10.1016/s0006-8993(00)03028-6

Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain

Brain Res. 2000 Dec 29;887(2):436-9. doi: 10.1016/s0006-8993(00)03028-6.

Authors

S Begon¹, G Pickering, A Eschalier, C Dubray

Affiliation

¹ INSERM EPI 9904, Pharmacologie Fondamentale et Clinique de la Douleur, Laboratoire de Pharmacologie Médicale, Faculté de Médecine, B.P. 38, 63001 Clermont-Ferrand, Cedex 1, France. sophie_begon@hotmail.com

PMID: 11134637
DOI: 10.1016/s0006-8993(00)03028-6

Abstract

Considering that magnesium and non-competitive NMDA receptor antagonists inhibit the opening of the channel linked to the NMDA receptor, we assessed their effects on mechanical hyperalgesia in two animal models of neuropathic pain (rats with a sciatic nerve ligature and diabetic rats). Our data show that magnesium reverses the hyperalgesia, as does MK-801. These results suggest that magnesium could be an alternative for the treatment of neuropathic pain in patients.

MeSH terms

Animals
Diabetes Mellitus, Experimental / physiopathology*
Diabetic Neuropathies / drug therapy
Diabetic Neuropathies / physiopathology
Disease Models, Animal
Dizocilpine Maleate / pharmacology*
Excitatory Amino Acid Antagonists / pharmacology
Hyperalgesia / drug therapy
Hyperalgesia / physiopathology*
Magnesium Sulfate / pharmacology*
Male
Neuralgia / drug therapy
Neuralgia / physiopathology*
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
Sciatic Nerve / physiology*

Substances

Excitatory Amino Acid Antagonists
Receptors, N-Methyl-D-Aspartate
Dizocilpine Maleate
Magnesium Sulfate