Successful bone marrow transplantation in a patient with Schimke immuno-osseous dysplasia

J Pediatr. 2000 Dec;137(6):882-6. doi: 10.1067/mpd.2000.109147.

Abstract

Early death in Schimke immuno-osseous dysplasia often results from renal failure and/or cell-mediated immunodeficiency. Kidney transplants have improved renal function, but effective therapy for the immunodeficiency has not yet been reported. We describe markedly improved marrow function 2 years after bone marrow transplantation in a boy with Schimke immunoosseous dysplasia.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, CD / blood
  • Bone Marrow Transplantation*
  • Child
  • Child, Preschool
  • Graft vs Host Disease / prevention & control
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Infant, Newborn
  • Kidney Transplantation
  • Lymphopenia / complications
  • Lymphopenia / diagnosis
  • Male
  • Osteochondrodysplasias / complications
  • Osteochondrodysplasias / genetics*
  • Osteochondrodysplasias / therapy*
  • Pedigree
  • Renal Insufficiency / complications
  • Renal Insufficiency / surgery
  • Tacrolimus / therapeutic use

Substances

  • Antigens, CD
  • Immunosuppressive Agents
  • Tacrolimus