From structure to function: approaches and limitations

Nat Struct Biol. 2000 Nov:7 Suppl:991-4. doi: 10.1038/80784.

Abstract

This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a protein in vivo will only be possible by including other results, such as data on expression and localization.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Binding Sites
  • Databases as Topic
  • Drug Design
  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Proteins / chemistry*
  • Proteins / classification
  • Proteins / genetics
  • Proteins / metabolism*
  • Structure-Activity Relationship

Substances

  • Proteins