Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis

Cancer Lett. 2000 Dec 20;161(2):201-5. doi: 10.1016/s0304-3835(00)00610-8.

Abstract

Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-beta-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-beta-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-beta-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-alpha-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation, were submitted to an in vivo two-stage mouse skin carcinogenesis test, using dimethylbenz[a]anthracene (DMBA) and TPA. The study was extended to two deacylated galactosylglycerol structures, 1-O-beta-D-galactopyranosyl-sn-glycerol (5) and 3-O-beta-D-galactopyranosyl-sn-glycerol (6). All the tested compounds exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion, the 1-hexanoate 2 being the most active among the glycoglycerolipids until now studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Antigens, Viral / metabolism
  • Antineoplastic Agents / pharmacology*
  • Biological Assay
  • Carcinogens
  • Female
  • Glycolipids / pharmacology
  • Lipids / chemistry*
  • Lipids / pharmacology*
  • Mice
  • Mice, Inbred ICR
  • Papilloma / chemically induced
  • Papilloma / prevention & control
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / metabolism*
  • Tetradecanoylphorbol Acetate / antagonists & inhibitors
  • Time Factors

Substances

  • Antigens, Viral
  • Antineoplastic Agents
  • Carcinogens
  • Epstein-Barr virus early antigen
  • Glycolipids
  • Lipids
  • 9,10-Dimethyl-1,2-benzanthracene
  • Tetradecanoylphorbol Acetate