Objective: To study hemodynamic the effects of intravenous diltiazem on COPD induced pulmonary hypertention.
Methods: 11 cases in exacerbation stage were chosen to study. Swan-Ganz catheterization were taken for hemodynamic monitoring.
Results: After the administration of diltiazem, pulmonary vascular resistance, pulmonary pressure, right artrial pressure and heart rate decreased significantly (the extents decreased were 14.0 kPa.s-1.L-1, 0.62-1.27 kPa, 0.27-0.40 kPa and 25-30 beats/min respectively, P < 0.05); Cardiac output and stroke volume increased identically (the extents increased were 0.3-0.6 L.min-1.m-2 and 5-9 ml.beat-1.m-2 respectively, P < 0.05); No significant changes found in Qs/Qt, PaO2 and systemic blood pressure.
Conclusion: Our study showed that diltiazem produces beneficial pulmonary hemodynamic effects without oxygenation compromise in COPD cases and has a strong indication in those who complicated with superventricular tachycardia.