Abstract
We report here the in vitro activity of a selection of 1, 2-aminoalcohol-containing compounds against cloned strains of human Plasmodium falciparum. These compounds exhibit moderate antimalarial activity but a high degree of strain specificity, preferentially inhibiting a chloroquine-resistant strain of the organism.
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Ethanolamines / chemistry
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Ethanolamines / pharmacology*
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Humans
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Leucine / analogs & derivatives*
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Leucine / chemistry
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Leucine / pharmacology
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Plasmodium falciparum / drug effects
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Protease Inhibitors / chemistry
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Protease Inhibitors / pharmacology*
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Species Specificity
Substances
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Antimalarials
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Ethanolamines
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Protease Inhibitors
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Leucine
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ubenimex