Abstract
Effective antiretroviral therapy leads to rapid decrease in plasma HIV-1 RNA, frequently followed by an increase in CD4 T-helper cell counts. The improvement of immune function during highly active antiretroviral therapy has important impact on natural history of AIDS-related opportunistic disorders. Here we describe cases of unusual clinical inflammatory syndromes in CMV retinitis, hepatitis C, and atypical mycobacteriosis in HIV-1 infected patients associated with the initiation of antiretroviral therapy. Pathogenetic implications and therapeutic management of these new immunopathologic syndromes are discussed.
MeSH terms
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AIDS-Related Opportunistic Infections / complications
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / immunology*
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AIDS-Related Opportunistic Infections / virology
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Acquired Immunodeficiency Syndrome / drug therapy
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Acquired Immunodeficiency Syndrome / immunology*
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Acquired Immunodeficiency Syndrome / virology
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Adult
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Anti-HIV Agents / therapeutic use*
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Antiretroviral Therapy, Highly Active*
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Cytomegalovirus Retinitis / complications
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Cytomegalovirus Retinitis / immunology*
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Female
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HIV Protease Inhibitors / therapeutic use
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HIV-1 / genetics
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HIV-1 / immunology*
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Hepatitis C / complications
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Hepatitis C / immunology*
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Humans
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Indinavir / therapeutic use
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Lamivudine / therapeutic use
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Male
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Middle Aged
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Mycobacterium avium-intracellulare Infection / complications
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Mycobacterium avium-intracellulare Infection / immunology*
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Reverse Transcriptase Inhibitors / therapeutic use
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Zidovudine / therapeutic use
Substances
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Anti-HIV Agents
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HIV Protease Inhibitors
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Reverse Transcriptase Inhibitors
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Lamivudine
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Zidovudine
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Indinavir