Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis

D L Boger; J K Lee

doi:10.1021/jo000382r

Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis

J Org Chem. 2000 Sep 22;65(19):5996-6000. doi: 10.1021/jo000382r.

Authors

D L Boger¹, J K Lee

Affiliation

¹ Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. boger@scripps.edu

PMID: 10987932
DOI: 10.1021/jo000382r

Abstract

The development of a solution phase synthesis of azatriostin A (2) suitable for the preparation of combinatorial libraries enlisting only liquid-liquid acid/base extractions for the isolation and purification of all intermediates and the final product is disclosed.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antibiotics, Antineoplastic / chemical synthesis*
Chromatography, High Pressure Liquid
Combinatorial Chemistry Techniques
Intercalating Agents / chemical synthesis*
Magnetic Resonance Spectroscopy
Quinoxalines / chemistry

Substances

Antibiotics, Antineoplastic
Intercalating Agents
Quinoxalines
triostin A

Grants and funding

CA 78045/CA/NCI NIH HHS/United States