Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii

J Nat Prod. 2000 Aug;63(8):1160-3. doi: 10.1021/np000063v.

Abstract

Investigation of extracts of Fissistigma balansae and Fissistigma oldhamii resulted in the isolation of 11 aristolactams-stigmalactam (1), piperolactam A (2), piperolactam C (3), aristolactam AII (4), aristolactam AIIIa (5), aristolactam BII (6), aristolactam BIII (7), aristolactam FII (8), goniothalactam (9), enterocarpam I (10), and velutinam (11)-as well as two dioxoaporphines, noraristolodione (12) and norcepharadione B (13). The new compound 1 was identified by spectral data interpretation. Compounds 1-13 were subjected to antiplatelet aggregation testing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Assay
  • Blood Platelets / drug effects
  • Cell Aggregation / drug effects
  • China
  • Chromatography, Gel
  • Chromatography, Thin Layer
  • Gas Chromatography-Mass Spectrometry
  • Lactams / chemistry
  • Lactams / isolation & purification*
  • Lactams / pharmacology
  • Magnetic Resonance Spectroscopy
  • Phenanthrenes / chemistry
  • Phenanthrenes / isolation & purification
  • Phenanthrenes / pharmacology
  • Plant Stems / chemistry*
  • Plants / chemistry
  • Rabbits
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Taiwan

Substances

  • Lactams
  • Phenanthrenes
  • stigmalactam