This study examined the differences in the prescription and administration of analgesics in eight pediatric specialty units. Medical records of patients (n = 153) who were reported by nurses to be having pain were reviewed. Results showed that there were variations in the type of analgesics prescribed and administered in the different units. Mean doses of opioids were slightly subtherapeutic. The mean doses of the nonsteroidal anti-inflammatory drugs and adjuvants were all within the therapeutic range. There were large intervals between doses of medications. Because few patients had pain scores recorded before and after analgesic administration, evidence of relief was inconclusive, and the actual effectiveness of analgesics could not be consistently evaluated. Undertreatment of pain may result from administration of subtherapeutic analgesic doses, long intervals between administrations of doses, lack of proper documentation to guide practice, or a combination of these reasons.