[Anti-HIV chemoprophylaxis for blood-exposure accidents]

Ann Med Interne (Paris). 2000 Jun;151(4):283-90.
[Article in French]

Abstract

Chemoprophylaxis against HIV after accidental blood exposures represents a new indication for antiretroviral drugs. Efficacy has been suggested by the results of a case-control study in health care workers and the reduction of mother to infant transmission of HIV with zidovudine. The post-exposure treatment should be given as soon as possible, and in the latest at 48 hours. National guidelines recommend a triple therapy with or without protease inhibitor, adapted to the source patient. The evaluation of efficacy needs a standardized follow-up.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Anti-HIV Agents / therapeutic use*
  • Case-Control Studies
  • Drug Therapy, Combination
  • France / epidemiology
  • HIV Infections / epidemiology
  • HIV Infections / etiology*
  • HIV Infections / prevention & control*
  • HIV Protease Inhibitors / therapeutic use
  • Health Personnel / statistics & numerical data
  • Humans
  • Infectious Disease Transmission, Vertical / prevention & control
  • Infectious Disease Transmission, Vertical / statistics & numerical data
  • Needlestick Injuries / complications*
  • Needlestick Injuries / epidemiology
  • Occupational Exposure / prevention & control
  • Occupational Exposure / statistics & numerical data
  • Patient Selection
  • Practice Guidelines as Topic
  • Risk Factors
  • Time Factors
  • Zidovudine / therapeutic use*

Substances

  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Zidovudine