Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae

FEBS Lett. 2000 Jul 28;478(1-2):84-8. doi: 10.1016/s0014-5793(00)01835-4.

Abstract

Deletion of the 1,3-beta-D-glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracellular delocalization of Chs3p and Chs4p, the two main components of the CSIII active complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier Proteins / metabolism
  • Cell Division
  • Chitin / biosynthesis*
  • Chitin Synthase / biosynthesis
  • Chitin Synthase / metabolism
  • Echinocandins
  • Enzyme Induction
  • Fungal Proteins / biosynthesis
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism
  • Fungal Proteins / physiology
  • Gene Deletion*
  • Gene Expression Regulation, Fungal
  • Glucosyltransferases*
  • Membrane Proteins / deficiency
  • Membrane Proteins / genetics*
  • Membrane Proteins / physiology
  • Phenotype
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins*

Substances

  • Carrier Proteins
  • Echinocandins
  • Fungal Proteins
  • Membrane Proteins
  • SKT5 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Chitin
  • Glucosyltransferases
  • Chitin Synthase
  • FKS1 protein, S cerevisiae