[The use of cycloferon in the therapy of experimental herpetic keratitis]

V P Sukhinin; V M Pleskov; V V Zarubaev; A V Slita; E A Pestrinskaia; V V Brzheskiĭ; A L Kovalenko; F I Ershov

[The use of cycloferon in the therapy of experimental herpetic keratitis]

Antibiot Khimioter. 2000;45(6):13-6.

[Article in Russian]

Authors

V P Sukhinin¹, V M Pleskov, V V Zarubaev, A V Slita, E A Pestrinskaia, V V Brzheskiĭ, A L Kovalenko, F I Ershov

Affiliation

¹ Influenza Research Institute, RAMS, St. Petersburg.

PMID: 10904803

Abstract

The cycloferon efficacy was investigated in the treatment of experimental herpesvirus kerato-conjunctivitis in rabbits. The model was demonstrated to reflect the main aspects of herpesvirus eye lesions in humans. Cycloferon application similarly to that of known interferon inducer poludan has been shown to enhance processes of inflammation and subsequent regeneration of eye tissues as well as to decrease mortality of animals due to the generalization of infection.

Publication types

Comparative Study

MeSH terms

Acridines / therapeutic use*
Animals
Drug Evaluation, Preclinical
Interferon Inducers / therapeutic use*
Iridocyclitis / diagnosis
Iridocyclitis / drug therapy
Iridocyclitis / pathology
Iridocyclitis / virology
Keratitis, Herpetic / diagnosis
Keratitis, Herpetic / drug therapy*
Keratitis, Herpetic / pathology
Keratitis, Herpetic / virology
Polyribonucleotides / therapeutic use
Rabbits
Simplexvirus / isolation & purification
Time Factors

Substances

Acridines
Interferon Inducers
Polyribonucleotides
poludan
10-carboxymethyl-9-acridanone