We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor (a so-called mesothelioma) of the atrioventricular nodal region. At autopsy the tumor was found to prolapse into and occlude the right coronary ostium, leading to an acute, recurring myocardial infarction. Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node. To our knowledge, this is the first report of co-existence of these two rare cardiac tumors.