Cloning, structural organization, and chromosomal assignment of the porcine c-fos proto-oncogene, FOS

Cytogenet Cell Genet. 2000;89(1-2):59-61. doi: 10.1159/000015565.

Abstract

The complete porcine c-fos proto-oncogene (FOS) with flanking regions was cloned and sequenced. FOS consists of four exons at amino acids 1-47, 48-131, 132-167, and 168-380 and includes all the typical motifs of the fos proto-oncogene. The promoter contains consensus sequences for CRE, SRE, CaRE, and the E-Box, as well as an AP-1 site. Homologies between human and swine were between 89.7% and 96.3% in the exons. Based on somatic cell hybrid panel screening and known homologies between swine chromosome 7 and human chromosome 14, the porcine c-fos gene was assigned to chromosome 7q23.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 14 / genetics
  • Cloning, Molecular
  • Exons / genetics*
  • Genes, fos / genetics*
  • Humans
  • Hybrid Cells
  • Introns / genetics*
  • Molecular Sequence Data
  • Proto-Oncogene Mas
  • Response Elements / genetics
  • Sequence Homology, Nucleic Acid
  • Swine / genetics*
  • TATA Box / genetics

Associated data

  • GENBANK/AJ132510