The classification of first episode schizophrenia: a cluster-analytical approach

Acta Psychiatr Scand. 2000 Jul;102(1):26-31. doi: 10.1034/j.1600-0447.2000.102001026.x.

Abstract

Objective: This paper examines, using data from the Cantabria First Episode Schizophrenia Study, the usefulness of subdividing, using a cluster analysis technique, this schizophrenia population into subgroups with similar symptoms profiles in terms of SANS and SAPS.

Method: Diagnostic characteristics were determined using the Present State Examination (PSE-9) and the SANS/SAPS. Premorbid adjustment was assessed using a scale developed combining the Gittelman and Klein's Scales, and the Goldstein's scales. Social Adjustment was evaluated using the WHO-DAS. In addition clinical histories were used to assess the patients' clinical course.

Results: Our schizophrenic patients could be subtyped into four categories: negative, positive non-paranoid, simple and disorganized schizophrenia. There is an absence of significant association between the majority of the variables investigated and the four-cluster model.

Conclusion: Even though our sample could be subtyped into different categories, the model does not show predictive power according to the 3-year follow-up data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Cluster Analysis
  • Confounding Factors, Epidemiologic
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Models, Psychological
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Reproducibility of Results
  • Schizophrenia / classification
  • Schizophrenia / diagnosis*
  • Schizophrenic Psychology*
  • Social Adjustment*